BeiGene started in Beijing with a handful of scientists and developers, each committed to discovering new oncology treatments, improving access focused on helping patients in China. Today, with a global team, a rich pipeline, strong partnerships, and commercial products, we have no borders.
We have built an extensive collection of novel in vitro, ex vivo and in vivo cancer models, in order to better select targets and to screen and evaluate agents that may have significant potential alone or in combination. Our cancer models also integrate elements of the human immune system, allowing us to evaluate potential drug candidates in conditions that approximate a patient’s cancer at the time of treatment. This is particularly significant when drug discovery requires evaluation not only of monotherapies but also multiple combinations and regimens targeting specific mutations while simultaneously immobilizing the defenses cancer cells mount against the human immune system.
R&D is an art as much as it is science. Our innovation team consists of dedicated scientists in biology, chemistry, pharmacology, translational medicine, and clinical science who are challenged with the mission of innovating tomorrow’s medicines. Their responsibility, their passion, is the opportunity to help the world’s cancer patients. Cancer has no borders and neither do we.
Now we have multiple positions open in Beijing/Shanghai, China. Talents in the field of immuno-oncology, immunology or cancer biology are warmly welcomed. If you’re interested or have friends to recommend, please do not hesitate to contact us via email: Catherine.fang@beigene.com
Discovery Biology Position (RI to D level):
This individual will design and execute proof of concept studies in pre-clinical models of tumor immunology and assist in cross-functional development of our research strategy. Design and execute in vitro experiments to screen immuno-oncology targets, identify and characterize how the therapeutic leads can modulate immune functions.
Collaborate with the broader scientific teams to design and execute experiments aimed at defining the mechanism(s) of action.
Work with in vivo team to develop in vivo models to test the activity of therapeutic leads in combination with established immunotherapeutic agents and perform in-depth characterization of immune responses in these models.
- Design and execute in vitro experiments to screen immuno-oncology targets, identify and characterize how the therapeutic leads can modulate immune functions.
- Collaborate with the broader scientific teams to design and execute experiments aimed at defining the mechanism(s) of action.
- Work with in vivo team to develop in vivo models to test the activity of therapeutic leads in combination with established immunotherapeutic agents and perform in-depth characterization of immune responses in these models.
- Engage colleagues in cross-disciplinary scientific discussion, present scientific data to internal and external audiences and keep abreast of relevant scientific literature.
In Vivo Pharmacology Position (PI/SPI level):
This individual will design, execute and lead in vivo and translational studies in animal models to develop both large/small molecular drugs and other treatment modalities, assisting or leading cross-functional cooperation of our research programs.
The primary responsibilities are to lead a group of scientists to discover and validate novel drug targets and support drug candidate screening and selection. The successful candidate will advance several aspects of BeiGene’s pre-clinical programs, using their skill sets to accomplish the following responsibilities.
- Design and execute in vivo/ex vivo experiment for the purpose of target validation, compound screening, selection, mechanism(s) investigation and IND filing.
- Engage in cross-disciplinary scientific discussion, act as the in vivo pharmacology representative to present scientific data to internal and external audiences.
- Propose and lead new program as needed.
- Review and evaluate target/program for due diligence purpose as needed.
- Other management responsibilities as needed.
Comparative Medicine Position(SPI/AD level):
Prospective candidates should have a passion for learning, strong technical, communication, and organizational skills as well as a sense of creativity. The Head of Comparative Medicine (CM) will be required to plan and oversee conduct of in-vivo studies to advance our lead research and development programs including: providing strategic direction for setting up the animal disease models, supervising animal study staff and relevant investigators, implementation and harmonizing procedures of animal studies, and facilitating Institutional Animal Care and Use committee (IACUC) reviews. The Comparative Medicine team has a significant role in the drug development process beginning in early discovery and continuing through the entire drug development value chain resulting in successful registration and marketing approval.
Key Responsibilities:
- Manage the existing and develop new animal disease models in Beigene.
- Supervise animal study staff including contractors.
- Support research investigators in protocol and animal model development, including but not limited to advising on study design and execution.
- Develop and provide corporate training program for all staff and contractors involved with animal research.
- Coordinate across CM and other functions groups, and partner with pharmacology leads.
- Serve as the key member of the Vivarium IACUC and lead internal compliance assessments.
- Contribute to the pharmacology departmental strategy forming and execution.
Principal Pathologist Position (PI/SPI/AD level):
Prospective candidates will join the in vivo pharmacology team to support programs in preclinical and clinical development stages. The individual will bring pathology expertise with hands-on approaches to guide preclinical decisions and assist with decision making as programs move to clinical trials. The individual will help to optimize the histology and toxicology approaches as the team grows, design studies and move the programs forward using high-quality tissue-based assays and data analysis. The individual will work cross-functionally with the project teams across a broad spectrum of portfolios including but not limited to Tumor Biology, Immuno-oncology and Autoimmune programs.
Responsibility
- Build, organize and operate a translational pathology laboratory
- Being a vital member of the team to develop and optimize pathology methods for drug R&D. This includes, but not limited to, techniques used for molecular pathology, histology, investigative pathology/toxicology
- Drive high quality data analysis relevant to pathology and manage data generated both internally and externally
- Build a state-of-the-art pathology technology platform, including but not limited to, methods of IHC, IF and ISH to support characterization of established and novel targets.
- Guide pathology and imaging decision making with teams as drug candidates approach clinical stages
- Provide expert guidance on pathology and other tissue-based assays for cross functional research and development teams as needed
- Contribute to the design and implementation of pathology laboratory information management system (LIMS)
- Comply with regulated laboratory standards for pathology and IHC documentation and reporting standards
- Contribute to IND/NDA/CTA filing as the pharmacology/toxicology section author
Translational Biology Position (RI to D level):
The primary responsibilities for this position are to lead a group of scientists to validate novel drug targets and explore novel mechanism. The candidate will also lead preclinical translational studies in solid tumor or hematological malignancies and develop translational and biomarker strategies for BeiGene’s drugs. Activities include carrying out mechanism of action studies, biomarker identification, generation of data that support clinical biomarker development, and assay set-up for the pharmacodynamic evaluation of drugs in the clinical setting.
- Design and execute in vitro and vivo experiments to evaluate drug leads (biologics and small molecules).
- Collaborate with the broader scientific teams to design and execute experiments aimed at defining the mechanism(s) of action.
- Work with in vitro team (chemistry, biologics and cell biology) to develop in vivo models to test the activity of therapeutic leads in combination with established therapeutic agents and perform in-depth characterization of mechanism in these models.
- Engage colleagues in cross-disciplinary scientific discussion, present scientific data to internal and external audiences and keep abreast of relevant scientific literature.
- Work together with clinical biomarker team to establish and validate biomarkers to support clinical trials.
