Immediate availability for a Postdoctoral position at the University of Washington, Seattle WA. The overall goals of the laboratory are to define the roles of specific signaling proteins in the development, functions, and transformation of immune cells utilizing murine models. Potential projects will focus on defining how loss-of-function mutations in specific genes result in Primary Immunodeficiency Diseases (PIDs) and autoimmunity. Project 1 involves investigating the mechanisms of how LOF mutations in Fnip1 alter immunometabolism and lymphocyte development (see Park et al., Immunity (PMID 22608497); Park et al., PNAS (PMID 24785297); Reyes et al., PNAS (PMID 24785297); Iritani et al., Blood (PMID 33507298)). Project 2 focuses on investigating how LOF mutations in a hematopoietic cell specific actin regulatory protein alter the development and functions of macrophages, T cells, and/or B cells (see Park et al., Journal of Experimental Medicine (PMID 19015308); Suwankitwat et al., Journal of Experimental Medicine (PMID 33600594); Peters et al Nat Genetics (PMID 28892060). Successful candidates will utilize a variety of innovative technologies including metabolomics, transcriptomics, epigenomics, proteomics, live cell imaging, and humanized mice.
Candidates should have a Ph.D., or equivalent degree in Immunology or Molecular and Cellular biology, and specific expertise in working with transgenic and knockout mice; utilizing flow cytometry to dissect immune development and functions; and basic biochemistry and molecular biology techniques. Expertise in live cell imaging is a plus. Qualifications also include strong interpersonal and organizational skills, and interests in mentoring undergraduate and graduate students, and collaborative attitude. A solid publication record as well as eligibility and desire to apply for future fellowships are helpful.
Interested applicants should send their CV, cover letter, and contact information for 3 references to Brian Iritani (biritani@uw.edu).
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